Unità di Oncologia Medica Traslazionale

Unità di Oncologia Medica Traslazionale con annesso Centro di Riferimento Regionale per il Counselling Genetico e Terapie ad elevato contenuto tecnologico -  Prof. Tassone Pierfrancesco
A proportion of human tumors (approximately 5%), such as breast, ovarian and colon cancer, may arise in hereditary background. This genetic condition is characterized by the presence of changes in genes involved in the control of growth and cell differentiation.

These changes are present in germ line cells and therefore can be transmitted to offspring. The hereditary cancers are characterized by early onset age and by an aggregation of multiple cases in the same family, such as in the hereditary breast and ovarian cancer syndrome (BRCA).

Genetic alterations that cause this syndrome are located on the genes BRCA1 or BRCA2, which in normal subjects play a role in relevant molecular events such as DNA repair. The CINBO Sa.Ve Working group is a network project that involves a number of academic institutions distributed throughout the national territory. Under this project this website has been developed to disseminate general information about hereditary cancer to health professionals, the public and the patients. This website also provides information on genetic counselling and on centers which have a specific experience in this field and offer such diagnostic services.

A further objective is to create a bridge of communication between different research institutions and working groups in different locations, studying the same aspects, and validate technology and information from the whole community.